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1. 基本信息
品系名称：B6-Tigitem1(hTigit)Vst/Vst
常用名：C57BL/6-Tigit人源化小鼠; Tigit人源化小鼠;Hu-Tigit
背景：C57BL/6NCrl
毛色：黑色
品系建立：
采用(yong)CRISPR-Cas9辅助的方法，将小(xiao)鼠Tigit基因(T Cell Immunoreceptor With Ig And ITIM Domains)替换(huan)为人源Tigit。这样在Tigit人源化(hua)小(xiao)鼠体内，使(shi)用(yong)人源Tigit抗体抑(yi)制剂时就(jiu)可以识别(bie)，进行相关的药效或药物(wu)筛选实验。
2. 应用领域(yu)
-人源化和(he)癌症治疗
-免疫治疗
-药(yao)物(wu)筛选
3. 参考文献
（1）The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.Yu X, Harden K, Gonzalez LC, Francesco M, Chiang E, Irving B, Tom I, Ivelja S, Refino CJ, Clark H, Eaton D, Grogan JL.Nat Immunol. 2009 Jan;10(1):48-57. doi: 10.1038/ni.1674. Epub 2008 Nov 16.
（2）Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering.Stengel KF, Harden-Bowles K, Yu X, Rouge L, Yin J, Comps-Agrar L, Wiesmann C, Bazan JF, Eaton DL, Grogan JL.Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5399-404. doi: 10.1073/pnas.1120606109. Epub 2012 Mar 15.
